As shown in Figure 2A and 2B the coating of Lm-spa + with the receptor-specific antibody led to a highly significant increase of Lm-spa + internalization (ranging from 2 × 10 2 - to 10 4 -fold) into tumor cells expressing the respective receptor on the surface.
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Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines.
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