Barely Significant
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TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

PLoS One · 2011 · PMC3144193 · PMID 21814547

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highly significantno p-value reported
Loos and colleagues reported a highly significant association of the T allele at rs7903146 with circulating fasting proinsulin and the proinsulin∶insulin ratio in healthy white adults from the United Kingdom [11] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.