A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes.

Genome Biol · 2001 · PMC31479 · PMID 11305938

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highly significantP < 10 -6actually significant

Differences between eukaryotes and bacteria, or between eukaryotes and the combined archaeal/bacterial data set, were highly significant ( P < 10 -6 that both represent samples drawn from the same population for each pairwise test). 5.

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