Low doses of the novel caspase-inhibitor GS-9450 leads to lower caspase-3 and -8 expression on peripheral CD4+ and CD8+ T-cells.

Expression of activated caspase-8 by CD8+ T-cells was also significantly higher in chronic HCV-patients compared to HC [median 10.3 (IQR 6.5–22.8) and 3.90 (IQR 3.2–7.3); P = 0.02] with a trend towards significance for the CD4+ T-cells [14.8 (IQR 7.5–41.0) and 6.7 (IQR 6.4–8.0); P = 0.07].

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