The presence of a greater than expected number of associated SNPs in genes of similar biological functions interacting within intricate biological pathways could give a degree of confidence that the associations are potentially genuine, even if none of the SNPs individually are highly significant. 14 While GWAS can effectively map loci conferring risk for breast cancer, they offer limited insights about the mechanisms by which the SNPs exert their effects or influence phenotypic expression.
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An integrative genomics approach to biomarker discovery in breast cancer.
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