Porphyromonas gingivalis gingipains trigger a proinflammatory response in human monocyte-derived macrophages through the p38α mitogen-activated protein kinase signal transduction pathway.

Toxins (Basel) · 2010 · PMC3153194 · PMID 22069588

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[ 27 ] reported a highly significant correlation between the levels of TNF-α and IL-8 in the periodontal tissues of diseased sites, suggesting that the expression of these two mediators is coordinated.

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