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TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1.

J Bone Miner Res · 2010 · PMC3154002 · PMID 20200974

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may be significantno p-value reported
This may be significant because enhanced or premature chondrocyte cell death may trigger subsequent events that accelerate degradation of cartilage.( 17 ) It was shown in articular chondrocytes that TNF-α-induced apoptosis was associated with increased expression of genes related to matrix degradation such as MMP and macr

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