A comparison of exogenous promoter activity at the ROSA26 locus using a ΦiC31 integrase mediated cassette exchange approach in mouse ES cells.

Similarly, UbC and MC1 driven expression also showed significantly higher expression when positioned in the sense orientation, although the effect was barely significant (p = 0.006 and p = 0.007, respectively) relative to the 0.006 p-value threshold obtained after adjusting for multiple comparisons.

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Despite the apparent lack of transcriptional read-through activity from the ROSA26 promoter into the inserted transgenes in this system, significant orientation dependent effects were observed for the EF1α promoter with borderline significant effects being recorded for the MC1 and the UbC promoters.

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