The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains.

Although the number of these mutations that have been sequenced to date is small it may be significant that missense point mutations are enriched at highly conserved residues, such as H1801P or L1815P, in comparison with non-sense and frameshift mutations ( Zentner et al, 2010 ) ( Figure 7B ), suggesting the structural integrity of the SLIDE domain could be important for the activity of CHD7 in development.

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