Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients.

Skelet Muscle · 2011 · PMC3156638 · PMID 21798095

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highly significantno p-value reported

A regression-based analysis using global test (GT) [ 16 ], and an enrichment method using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) [ 17 , 18 ] revealed highly significant deregulation of ubiquitin-proteasome system (UPS)-related GO (Gene Ontology) categories and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways across species (Table 1 ).

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