Caspase-3, myogenic transcription factors and cell cycle inhibitors are regulated by leukemia inhibitory factor to mediate inhibition of myogenic differentiation.

LIF alters transcripts of myogenic regulators and prevents decreases in proliferation caused by induction of differentiation Analysis using real-time qPCR of transcripts important for myoblast differentiation showed an overall trend for decreased levels of positive regulators of myogenesis shortly after LIF treatment (Figure 4A ).

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