The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.

It should be noted that although it appears that Acf1-GFP (but not native GFP) was precipitated less efficiently by the GFP-specific antibodies in the presence of E4orf4 ( Figures 1 E and 4 D), this altered efficiency was not detected when endogenous Acf1 was immunoprecipitated with Acf1-specific antibodies ( Figure 1 A and data not shown), and thus may not be significant.

also in 2,774 other papers