In fact, the role of CypE in influenza virus replication may be significant if 100% of the transfected cells were CypE over-expressing or knocked-down, but the inhibitory efficiency of CypE was not comparable to that of anti-influenza drugs.
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Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex.
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