Physical activity attenuates the effect of low birth weight on insulin resistance in adolescents: findings from two observational studies.

The P value for interaction was 0.048, and the association between birth weight and HOMA-IR was borderline significant in the low–physically active group (β = –0.089, P = 0.07), whereas no evidence of association was observed in the high–physically active group (β = –0.018, P = 0.74).

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The interaction effect observed was marginally significant; however, the fact that this finding was observed in two different epidemiological studies conducted on adolescents strengthens the conclusions.

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