The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

PLoS Genet · 2011 · PMC3164695 · PMID 21909281

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highly significantno p-value reported

Interestingly, sequence analysis (by scansite.mit.edu) predicts that HCF-1 contains a highly significant consensus 14-3-3 binding site, suggesting HCF-1 may directly bind 14-3-3.

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