25 Importantly, a highly significant reduction in the incidence of death from CVD with statin therapy vs control was observed both in individuals with established CHD (RR: 0.82; 95% confidence interval [CI]: 0.76–0.88) and in primary prevention (RR: 0.81; 95% CI: 0.75–0.87). 25 Secondary prevention The meta-analysis by Mills et al 25 included 42 studies of patients with CHD as the primary study population.
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