Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.

Indeed, under replicating conditions loss of ATM appears to have a more severe impact than the hypomorphic mutation in DNA ligase IV (compared to a similar impact under non-replicating conditions), suggesting that the checkpoint role of ATM may be significant.

also in 13,097 other papers

While there are multiple, overlapping pathways for base excision repair (BER) and SSB repair, such that loss of proteins involved in the repair pathways tends to slow but not abolish repair, DSBs are repaired more slowly and loss of the major DSB rejoining pathway is highly significant.

also in 132,142 other papers