Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia.

Nonetheless, the slower MTX elimination was statistically highly significant, and since the RFC1 A 80 variant may have a stronger impact on cellular MTX uptake and elimination rate than chromosome 21 trisomy, the findings by Buitenkamp [ 31 ] support the findings of by Gregers [ 21 ].

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