Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration.

Regional volumetric data were not available for one case in the TDP-A group; the small FUS group was excluded from logistic regression analyses. In univariate logistic regression analyses (thresholded at significance level P < 0.05), Pick's disease was associated with smaller mean putaminal and frontal lobe volumes, and greater hemispheric asymmetry; MAPT mutations with less hemispheric asymmetry; corticobasal degeneration with larger mean hippocampal, amygdala and temporal lobe volumes and with less hemispheric asymmetry (last association borderline significant, P = 0.066); TDP-C pathology with larger mean putaminal, cingulate and frontal lobe volumes and with smaller mean temporal lobe volume (last association borderline significant, P = 0.069); and TDP-A pathology with smaller cingulate volume (borderline significant, P = 0.054).

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