Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data.

The ordered relationship between tumor grade and position along the PC-3 axis is highly significant (Spearman rank-order correlation coefficient r s = 0.88, p = 0.003).

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Given the different microarray platforms, analytic techniques, and reporting strategies employed in the different studies negative results from this comparison should be interpreted cautiously (the failure of a gene to be reported as being differentially expressed in multiple studies does not indicate that the gene is not in fact differentially expressed in RCC), but agreement across multiple papers may be significant – especially given the differences between the studies.

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