Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma.

Interestingly, whereas the entire set of genes up-regulated in the mouse tumors did not have a predictive power (see above, Table 1 and Table S4 ), the subset of genes that were up-regulated in both mouse and human tumors showed marginally significant predictive power ( Table 2 , Table S7 ).

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We found that the genes down-regulated both in mouse and human tumors ( Table S6 ) retained a highly significant predictive power for survival and enrichment for metabolic processes.

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