A study of the evolution of human microRNAs by their apparent repression effectiveness on target genes.

PLoS One · 2011 · PMC3177854 · PMID 21957473

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an interesting trendno p-value reported

The comparison of the rARE values among miRNAs showed an interesting trend among different conservational categories.

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an increasing trendno p-value reported

Using the ARE measuer, we found that more conserved miRNAs have significantly higher repression effectiveness on the target genes than less conserved miRNAs on average, which can be explained by the existence of an increasing trend in miRNA evolution to secure more target genes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.