Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.

Although the exact consequence of this association remains unknown, the fact that VDBP has immunomodulatory characteristics and is responsible for transport of vitamin D metabolites supports, in theory, a model whereby the impact of reduced serum levels may be significant enough to lend itself, directly or indirectly, to the autoimmune destruction of pancreatic β-cells in the disease.

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