Impaired glucose tolerance in the absence of adenosine A1 receptor signaling.

No difference was seen between A1AR −/− mice on the HFD at 20–22 weeks compared with the standard diet at 20 weeks ( P = 0.25), whereas in wild-type mice, the HFD led to a markedly significant lower ISI compared with the standard diet ( P < 0.0001), a lower index representing decreased insulin sensitivity ( Fig. 5 ).

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