Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

We found a highly significant association (P = 1.0×10 −124 ) of the risk allele at the LIPA locus with LIPA mRNA levels in these cells explaining ∼50% of the variance in the expression of the gene ( Figure 6 ).There were no other highly significant associations between CAD risk alleles and gene expression at the novel loci ( Table S7a and S7b ).

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