an increasing trendP = 0.014
In the wavefront- optimized group, root mean square of total higher-order aberration ( P = 0.091), coma ( P = 0.115), and trefoil ( P = 0.459) all showed an increasing trend 3 months postoperatively, with a statistically significant two-fold increase in spherical aberration ( P = 0.014, Figure 2 ).