Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis.

Drug Des Devel Ther · 2011 · PMC3180514 · PMID 21966212

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of borderline significanceno p-value reported

The authors again reported loss of lung density in both groups with a difference of borderline significance in favor of the treatment group over the entire treatment period in one of four analysis methods.

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