a decreasing trendp < 0.001
Over time, there has been a decreasing trend for PCV7 serotypes (R 2 = 0.944; p < 0.001, with significant decreasing trends for serotypes 19F, 14, 23F and 9V), and increasing trends for serotype 19A (R 2 = 0.901; p < 0.001), serotype 3 (R 2 = 0.463; p = 0.030) and other non-PCV7 serotypes (R 2 = 0.877; p < 0.001), but not for serotype 6A (R 2 = 0.311; p = 0.094).