178 Two out of three in vitro stimulation studies showed no difference between schizophrenia patients and healthy controls, 174 , 179 while one described a highly significant increase in IL-10 production of chronically ill schizophrenia patients, compared with healthy controls, with medium levels in the subgroup of paranoid schizophrenia patients. 180 Peripheral administration of IL-6 induces increased dopamine and 5-HT turnovers in the hippocampus and frontal cortex of rodents, without influencing the metabolism of norepinephrine. 114 Within the brain, IL-6 is produced not only by glial cells, but also by neurons. 181 Thus, IL-6 is of interest in schizophrenia research.
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