170 While we previously reported no differences in luteal phase allopregnanolone and pregnanolone levels in women with PM'S compared with controls, 171 in an experimental model of postpartum depression (PPD), we observed a highly significant inverse correlation (r=0.92) between the change in allopregnanolone levels from weeks 6 to 8 of hormone addback and Beck depression ratings at week 8 of addback (see below). 172 This correlation reflected the high depression ratings in those women with a past history of PPD, whose allopregnanolone levels dropped or failed to increase during the last 2 weeks of high dose addback.
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