A highly significant hypermethylation was detected in both male and female samples at two loci: RPP21, which encodes a component of ribonuclease P, a complex that forms t-RNA molecules via 5'-end cleavage, and KEL, which encodes the Kell blood-group glycoprotein and causes McLeod Syndrome when incorrectly expressed; SZ symptoms are manifested as part of McLeod Syndrome.
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