The close proximity of Arg-118 (GyrA 121) to the fluoroquinolone 3-carboxyl group suggests that an interaction there might be significant to drug binding, which should be reflected in the recovery of resistance substitutions.
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The close proximity of Arg-118 (GyrA 121) to the fluoroquinolone 3-carboxyl group suggests that an interaction there might be significant to drug binding, which should be reflected in the recovery of resistance substitutions.