Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.

Although we were unable to detect ex vivo CD8 T cell responses to this epitope in the Irish cohort, the highly significant HLA-A*03 ‘footprint’ provides robust evidence that this epitope was likely to have been under considerable T cell-mediated selection pressure relatively early on in the course of infection.

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