The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology.

The average number of nominations was similar across the generations and by geographical area, but increased with higher socioeconomic status (2.9 for the highest, 2.3 for the lowest) and was greatest for women aged 45–54 years (3.0) and less at younger and older ages than this (e.g., 2.2 for ages 16–24; 1.9 for age 65 and older) (these differences are highly significant, P <0.001).

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