Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.

41 A single dose of TRP601 (5 mg/kg; i.p.) administered before occlusion induces a highly significant reduction (59%) of infarction (8.83±1.8% n =24) compared with the control (21.67±1.65% n =15) ( Figure 2a ).

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