A highly significant inverse relationship among all transgenic lines was noted in which the greater were the levels of global SUMOylation, the less was the extent of infarct damage in the brains of animals exposed to permanent middle cerebral artery occlusion (pMCAO) for 24 hours.
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Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage.
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