Barely Significant
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Coevolution of amino acid residues in the key photosynthetic enzyme Rubisco.

BMC Evol Biol · 2011 · PMC3190394 · PMID 21942934

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highly significantp -values < 10 -15actually significant
This test was highly significant for all four types (charge, volume, polarity and Grantham distance) of coevolving groups ( p -values < 10 -15 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.