Serum levels of tryptophan, 5-hydroxytryptophan and serotonin in patients affected with different forms of amenorrhea.

10 , 11 We have demonstrated that tryptophan has cyclical variation during the menstrual cycle showing a negative correlation with gonadotropins concentration in a highly significant way. 6 It was demonstrated that also 5-hydroxytryptophan, representing the immediate precursor of 5-HT along the “serotonin pathway”, can influence LH secretion in women in the follicular phase acting on GnRH release stimulation by hypothalamus or increasing the sensitivity of the pituitary to GnRH. 12 In this study, we aimed to analyse serum levels of tryptophan (Trp), 5-hydroxytryptophan (5-HTP) and serotonin (5-HT) in women affected with differently caused amenorrhea: anorexia nervosa, functional hypothalamic amenorrhea, and hyperprolactinemia.

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