Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice.

A logistic regression of this dataset, with presence or absence of a cilium as the dependent variable, and age, transgenic status, neuron size (ie >20 μm), and sex as predictive variables, shows that presence of a mutant transgene is a highly significant predictor of reduced ciliation (p < 0.001), as is large neuron size (p < 0.001).

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