Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium.

Neurobiol Aging · 2012 · PMC3200140 · PMID 20471138

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With respect to a possible molecular basis for the exaggerated CNS responses to systemic inflammation we have shown here that a number of key receptors for local responses to LPS and inflammatory cytokines are elevated in the ME7 hippocampus (TLR4, IL-1RI, TNFR p55, IFNAR2), and this may be significant in the priming of this region to inflammatory insults.

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