Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies.

In the total EPIC-Norfolk cohort excluding participants with prevalent T2D there was no evidence for a significant association between the genotype of rs198389 and cardio-metabolic characteristics including BMI; waist circumference; systolic and diastolic blood pressure; total, low-density lipoprotein, and high-density lipoprotein cholesterol; triglycerides; alcohol consumption; levels of serum uric acid, serum creatinine, and C-reactive protein; history of hypertension; smoking; and family history of diabetes ( n between 15,049 and 19,746), although there was a borderline significant association of lower systolic and diastolic blood pressure and a lower rate of history of hypertension with the C allele of rs198389 (all p = 0.07; Table S2 ).

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