35 Following 14 days of withdrawal, there was still a highly significant increase in mu-opioid receptor density, and primarily in specific brain regions, again where there are dopaminergic terminals from the ventral tegmental area neurons and in fields in close proximity to both muopioid receptor mRNA levels in the neurons producing mu-opioid receptors and presenting them on the cell surface. 35 In a further set of studies, Bailey explored changes in the kappa-opioid receptors following 14-day withdrawal from escalating-dose binge-pattern cocaine. 36 Here, very different findings were made.
1
—
—