Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

In complex diseases such as SLE, where many different genes make a modest contribution to disease susceptibility, it is necessary to perform large-scale association studies to combine results from several datasets, to have sufficient power to identify highly significant novel loci ( P <5×10 −8 ).

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These analyses increased the evidence of association for a number of additional loci that had shown borderline significance in the original US/SWE GWAS ( Table 3 ), including CFB , C12ORF30 , SH2B3 , and IL12B .

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