Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.

Int J Nanomedicine · 2011 · PMC3205141 · PMID 22072882

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a decreasing trendno p-value reported

A decreasing trend in the skin fluxes of Evo and Rut was observed when the water weight fraction in the ME was greater or less than 50%.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.