Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE(-/-) mouse model.

Infection with RAd66 alone increased plaque coverage (50% compared to 30%) compared to vehicle, although this failed to reach significance. 3.2 LOXIN ameliorates LOX-1 contribution to atherogenesis In order to assess the effect of co-expressing the ‘dominant-negative’ splice variant LOXIN on the LOX-1 enhancement of atherogenesis, we transduced arteries with both vectors as part of the same experiment.

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