Preventing deep vein thrombosis after stroke: strategies and recommendations.

Antithrombotic treatment in patients with ischemic stroke Unfractionated heparin In a Cochrane meta-analysis, the use of subcutaneous and intravenous unfractionated heparin, low-molecular-weight heparins, subcutaneous and intravenous heparinoids, oral vitamin K antagonists, and specific thrombin inhibitors was associated with a highly significant reduction in the risk of DVT in patients with ischemic stroke (OR, 0.21; 95% CI, 0.15–0.29), although the majority of DVTs detected were subclinical and asymptomatic [ 16 ].

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Intermittent pneumatic compression A meta-analysis of two trials with a total of 177 patients showed that the use of intermittent pneumatic compression within the first week after stroke onset was associated with a nonsignificant trend towards a lower risk of DVT (OR, 0.45; 95% CI, 0.19–1.10), with no evidence of an effect on deaths (OR, 1.04; 95% CI, 0.37–2.89) [ 13 ].

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