Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma.

These networks are highly significant in terms of both score and topological structure measurements (no random case outperformed the real case, P rand < 1.0 × 10 -3 , P perm < 1.0 × 10 -2 , P topo < 1.0 × 10 -3 ), which can be explained by a high proportion of differentially expressed genes (DEG) and hub proteins in the networks.

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