Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk.

BMC Med Genet · 2011 · PMC3213201 · PMID 22029572

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highly significantno p-value reported

Many SNPs that appear to be insignificant when examined independently, or uninformed sets that are weakly predictive of disease state, could be highly significant and predictive when examined as a set composed of SNPs from genes that work in concert within a pathway [ 38 ].

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