Origins and evolution of the HET-s prion-forming protein: searching for other amyloid-forming solenoids.

Searching for the conserved HeLo domains using the HMM also yielded a significant match to a HET-s/LopB domain from Metarhizium anisopliae ARSEF 23 [GI: 322703231, E-value 1.6e-10], as well as marginally significant matches [GI: 310797955, GI: 317157340, GI: 317033349] in several proteins from Glomerella graminicola , Aspergillus oryzae RIB40, and Aspergillus niger CBS 513.88, respectively [corresponding E-values 0.0042, 0.00082, 0.00083].

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This protein was identified in the NR database with marginal significance levels (E< = 0.010 in psiblast iterations).

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