Large scale mitochondrial sequencing in Mexican Americans suggests a reappraisal of Native American origins.

The high values of diversity indices (nucleotide diversity = 0.000615 and θ π = 9.5) along with high θ k (415.4) and highly significant negative Fu's Fs (-21.7, p = 0.00) of haplogroup A2 in North America may indicate a secondary expansion of the A2 haplogroup following the path represented by the ice free corridor between the Laurentide and Cordilleran ice sheets.

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